Applications

• Chemical precursor
• Lab reagent
• Liquid chromatography
• NMR Spectroscopy
• Mass spectrometer calibration

General

What is Trifluoroacetic Acid? It is a synthetic organofluorine compound with the chemical formula CF3CO2H. It is a haloacetic acid, with all three of the acetyl group's hydrogen atoms replaced by fluorine atoms. It is a colourless liquid with a vinegar-like odor. TFA is a stronger acid than acetic acid.

Consistent Quality: We provide only high-quality Trifluoroacetic Acid 99.5% ensuring reliable and consistent performance for all applications.

Sourced and bottled in non-toxic, chemical-resistant containers to ensure safe handling and preserve product quality during transport.

Glass Winchester Bottle: Available in 100ml, 250ml, 500ml and 1L pack sizes. Our Glass Winchester bottles can store chemicals that may be sensitive to light due to filtering potentially harmful UV rays. Bottles are durable, versatile and perfect for storing products in the chemical, pharmaceutical and cosmetic industries.

Frequent Uses

Chemical synthesis
TFA is the precursor to many other fluorinated compounds such as trifluoroacetic anhydride, trifluoroperacetic acid, and 2,2,2-trifluoroethanol.

General lab reagent
It is a reagent used in organic synthesis because of a combination of convenient properties: volatility, solubility in organic solvents, and its strength as an acid. TFA is also less oxidising than sulfuric acid but more readily available in anhydrous form than many other acids. One complication to its use is that TFA forms an azeotrope with water (b. p. 105 °C). TFA is used as a strong acid to remove protecting groups such as Boc used in organic chemistry and peptide synthesis.

Liquid chromatography
At a low concentration, TFA is used as an ion pairing agent in liquid chromatography (HPLC) of organic compounds, particularly peptides and small proteins.

Spectroscopy
TFA is a versatile solvent for NMR spectroscopy (for materials stable in acid).

Mass spectrometry
Also used as a calibrant in mass spectrometry.

Specification

• Minimum Assay: 99.5%
• Molecular Formula: C2HF3O2
• Molecular Weight: 114.02
• Boiling Point: 71.8 deg C
• Freezing Point: -15.2 deg C
• Melting Point: -15°
• Density: 1.489
• Refractive Index: 1.2840
• Colour: Water: < 0.05%
• Residue: <0.005%
• Unspecified Impurities by GC: <0.05%
• Identity: by GC

Hazards

Packing Group: 1

Hazard Phrases: Causes severe skin burns and eye damage. Harmful if inhaled. Harmful to aquatic life with long lasting effects.

Prec Phrases: Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.